Mytilopsis africana is a species of bivalve mollusc in the false mussel family, Dreissenidae. It is widespread along the brackish water environments of coastal West and Central Africa. It may represent a lineage of Mytilopsis sallei, a Caribbean species, that invaded the western coast of Africa during the period of slave trade.
Mytilopsis africana is a brackish water species that is widespread along lagoons, mangroves, and associated habitats. It grows attached to hard surfaces such as rocks, shells, and branches.