MYT1 explained

Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.

Interactions

MYT1 has been shown to interact with PIN1.^[4]

Further reading

• Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M . Plasticity in the adult human oligodendrocyte lineage . The Journal of Neuroscience . 14 . 8 . 4571–87 . Aug 1994 . 7519254 . 10.1523/JNEUROSCI.14-08-04571.1994. 6577192 .
• Armstrong RC, Kim JG, Hudson LD . Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes . Glia . 14 . 4 . 303–21 . Aug 1995 . 8530187 . 10.1002/glia.440140407 . 38779689 .
• Liu F, Stanton JJ, Wu Z, Piwnica-Worms H . The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex . Molecular and Cellular Biology . 17 . 2 . 571–83 . Feb 1997 . 9001210 . 231782 . 10.1128/mcb.17.2.571.
• Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD . Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system . Journal of Neuroscience Research . 50 . 2 . 272–90 . Oct 1997 . 9373037 . 10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A . 37120295 .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 5 . 6 . 355–64 . Dec 1998 . 10048485 . 10.1093/dnares/5.6.355 . free .
• Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Research . 6 . 3 . 197–205 . Jun 1999 . 10470851 . 10.1093/dnares/6.3.197 . free .
• Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S . Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia . Brain Research. Developmental Brain Research . 140 . 1 . 85–92 . Jan 2003 . 12524179 . 10.1016/S0165-3806(02)00585-0 .
• Nielsen JA, Berndt JA, Hudson LD, Armstrong RC . Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells . Molecular and Cellular Neurosciences . 25 . 1 . 111–23 . Jan 2004 . 14962745 . 10.1016/j.mcn.2003.10.001 . 28151272 .
• Vana AC, Lucchinetti CF, Le TQ, Armstrong RC . Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS . Glia . 55 . 7 . 687–97 . May 2007 . 17330875 . 2789289 . 10.1002/glia.20492 .

Notes and References

1. Kim JG, Hudson LD . Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene . Molecular and Cellular Biology . 12 . 12 . 5632–9 . Dec 1992 . 1280325 . 360502 . 10.1128/mcb.12.12.5632.
2. Booher RN, Holman PS, Fattaey A . Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity . The Journal of Biological Chemistry . 272 . 35 . 22300–6 . Aug 1997 . 9268380 . 10.1074/jbc.272.35.22300 . free .
3. Web site: Entrez Gene: MYT1 myelin transcription factor 1.
4. Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T . The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression . Journal of Cell Science . 112 . 19 . 3361–71 . Oct 1999 . 10.1242/jcs.112.19.3361 . 10504341 .