| Mirishkor District | |
| Official Name: | Mirishkor tumani |
| Other Name: | Миришкорский район |
| Settlement Type: | District |
| Mapsize: | 270px |
| Pushpin Map Caption: | Location in Uzbekistan |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name: |  Uzbekistan |
| Subdivision Name1: | Qashqadaryo Region |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Yangi Mirishkor |
| Leader Title: | Hokim |
| Leader Name: | Sherali Sanaev |
| Area Total Km2: | 3210 |
| Population As Of: | 2021 |
| Population Total: | 121500 |
| Population Density Km2: | auto |
| Timezone: | UZT |
| Utc Offset: | +5 |
Mirishkor District (Uzbek: Mirishkor/Миришкор; Tajik: Миришкор; Russian: Миришкар|Mirishkar) is a district of Qashqadaryo Region in Uzbekistan. The capital lies at the town Yangi Mirishkor.[1] It has an area of [2] and its population is 121,500 (2021 est.).[3] The district consists of 3 urban-type settlements (Yangi Mirishkor, Jeynov, Pomuq) and 12 rural communities.[1] It borders with Turkmenistan, Bukhara Region, Muborak District, Kasbi District, Nishon District.
Mirishkor has a cold desert climate (Köppen climate classification BWk). The district has mild winters, but very hot and dry summers. The average June temperature is about .
Natural resources include significant petroleum and natural gas reserves. Major agricultural activities include cotton, various crops and livestock.