Myosin-2 Explained

Myosin-2 (myosin heavy chain 2) is a protein that in humans is encoded by the MYH2 gene.^{[1] [2]}

Further reading

• Schwartz CE, McNally E, Leinwand L, Skolnick MH . A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13. . Cytogenet. Cell Genet. . 43 . 1–2 . 117–20 . 1987 . 2877813 . 10.1159/000132307 .
• Ennion S, Sant'ana Pereira J, Sargeant AJ, etal . Characterization of human skeletal muscle fibres according to the myosin heavy chains they express . J. Muscle Res. Cell. Motil. . 16 . 1 . 35–43 . 1995 . 7751403 . 10.1007/BF00125308 . 22270940 .
• Hisatome I, Morisaki T, Kamma H, etal . Control of AMP deaminase 1 binding to myosin heavy chain . Am. J. Physiol. . 275 . 3 Pt 1 . C870–81 . 1998 . 9730972 . 10.1152/ajpcell.1998.275.3.C870.
• Weiss A, McDonough D, Wertman B, etal . Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved . Proc. Natl. Acad. Sci. U.S.A. . 96 . 6 . 2958–63 . 1999 . 10077619 . 10.1073/pnas.96.6.2958 . 15877 . 1999PNAS...96.2958W . free .
• Weiss A, Schiaffino S, Leinwand LA . Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity . J. Mol. Biol. . 290 . 1 . 61–75 . 1999 . 10388558 . 10.1006/jmbi.1999.2865 .
• Onuoha GN, Alpar EK, Laprade M, etal . Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle . Clinical and Investigative Medicine . 22 . 5 . 180–4 . 1999 . 10579056 .
• Martinsson T, Oldfors A, Darin N, etal . Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene . Proc. Natl. Acad. Sci. U.S.A. . 97 . 26 . 14614–9 . 2001 . 11114175 . 10.1073/pnas.250289597 . 18967 . free .
• Tajsharghi H, Thornell LE, Darin N, etal . Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age . Neurology . 58 . 5 . 780–6 . 2002 . 11889243 . 10.1212/wnl.58.5.780. 31098150 .
• England K, Ashford D, Kidd D, Rumsby M . PKC epsilon is associated with myosin IIA and actin in fibroblasts . Cell. Signal. . 14 . 6 . 529–36 . 2002 . 11897493 . 10.1016/S0898-6568(01)00277-7 .
• Allen DL, Leinwand LA . Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter . J. Biol. Chem. . 277 . 47 . 45323–30 . 2003 . 12235157 . 10.1074/jbc.M208302200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Kim EJ, Helfman DM . Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin . J. Biol. Chem. . 278 . 32 . 30063–73 . 2003 . 12756252 . 10.1074/jbc.M304909200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chung MC, Kawamoto S . IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation . J. Biol. Chem. . 279 . 53 . 56042–52 . 2005 . 15496418 . 10.1074/jbc.M404791200 . free .
• Tajsharghi H, Darin N, Rekabdar E, etal . Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2) . Eur. J. Hum. Genet. . 13 . 5 . 617–22 . 2005 . 15741996 . 10.1038/sj.ejhg.5201375 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Li M, Lionikas A, Yu F, etal . Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys) . Neuromuscul. Disord. . 16 . 11 . 782–91 . 2006 . 17005402 . 10.1016/j.nmd.2006.07.023 . 1693964 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S . Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle . Am J Physiol . 267 . 6 Pt 1 . C1723–8 . Jan 1995 . 7545970 . 10.1152/ajpcell.1994.267.6.C1723.
2. Web site: Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult.