Myogel Explained

Myogel is a trade name for a human-based extracellular matrix used in cancer research to provide a 3D cell culture environment for cancer cells. Unlike other synthesized matrices such as matrigel which originated from mice sarcoma, myogel is extracted from a human benign tumor tissue called leiomyoma. Myogel was developed in Tuula Salo's lab at the University of Oulu. The idea started in 2009 by culturing cancer cells on myoma discs.^[1] Later in 2015, these myoma tissues were processed following matrigel receipt, to extract a gel form called Myogel.^[2] Myogel was compared with matrigel and found to be superior in term of enhancing cancer cells proliferation, migration and invasion.

Notes and References

1. Nurmenniemi . Sini . Sinikumpu . Teemu . Alahuhta . Ilkka . Salo . Sirpa . Sutinen . Meeri . Santala . Markku . Risteli . Juha . Nyberg . Pia . Salo . Tuula . September 2009 . A Novel Organotypic Model Mimics the Tumor Microenvironment . The American Journal of Pathology . en . 175 . 3 . 1281–1291 . 10.2353/ajpath.2009.081110. 19679876 . 2731146 .
2. Salo . Tuula . Sutinen . Meeri . Hoque Apu . Ehsanul . Sundquist . Elias . Cervigne . Nilva K. . de Oliveira . Carine Ervolino . Akram . Saad Ullah . Ohlmeier . Steffen . Suomi . Fumi . Eklund . Lauri . Juusela . Pirjo . December 2015 . A novel human leiomyoma tissue derived matrix for cell culture studies . BMC Cancer . en . 15 . 1 . 981 . 10.1186/s12885-015-1944-z . 26673244 . 4682271 . 17598911 . 1471-2407. free .