Mycothiol synthase explained

Mycothiol synthase
Ec Number:	2.3.1.189

Mycothiol synthase (MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

\rightleftharpoons CoA + mycothiol

This enzyme catalyses the last step in the biosynthesis of mycothiol

Notes and References

1. Spies HS, Steenkamp DJ . Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis . European Journal of Biochemistry . 224 . 1 . 203–13 . August 1994 . 8076641 . 10.1111/j.1432-1033.1994.tb20013.x .
2. Koledin T, Newton GL, Fahey RC . Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes . Archives of Microbiology . 178 . 5 . 331–7 . November 2002 . 12375100 . 10.1007/s00203-002-0462-y .
3. Vetting MW, Roderick SL, Yu M, Blanchard JS . Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases . Protein Science . 12 . 9 . 1954–9 . September 2003 . 12930994 . 2323992 . 10.1110/ps.03153703 .