| Mxolisi Mthethwa | |
| Fullname: | Mxolisi Mthethwa |
| Birth Date: | 18 September 1978 |
| Birth Place: | Swaziland |
| Position: | Midfielder |
| Years1: | 2000–2004 |
| Clubs1: | Manzini Wanderers |
| Years2: | 2004– |
| Clubs2: | Royal Leopards |
| Nationalyears1: | 2000– |
| Nationalcaps1: | 39 |
| Nationalgoals1: | 1 |
Mxolisi Mthethwa (born 18 September 1978) is a Liswati former footballer who played as a midfielder.