Muskelin Explained

Muskelin is a protein that in humans is encoded by the MKLN1 gene.^{[1] [2]}

Interactions

MKLN1 has been shown to interact with RANBP9.^[3]

Further reading

• Adams JC, Seed B, Lawler J . Muskelin, a novel intracellular mediator of cell adhesive and cytoskeletal responses to thrombospondin-1 . EMBO J. . 17 . 17 . 4964–74 . 1998 . 9724633 . 10.1093/emboj/17.17.4964 . 1170825 .
• Hasegawa H, Katoh H, Fujita H, etal . Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin . Biochem. Biophys. Res. Commun. . 276 . 1 . 350–4 . 2000 . 11006128 . 10.1006/bbrc.2000.3467 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Umeda M, Nishitani H, Nishimoto T . A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM . Gene . 303 . 47–54 . 2003 . 12559565 . 10.1016/S0378-1119(02)01153-8 .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Prag S, Collett GD, Adams JC . Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association . Biochem. J. . 381 . Pt 2 . 547–59 . 2004 . 15084145 . 10.1042/BJ20040253 . 1133863 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Kobayashi N, Yang J, Ueda A, etal . RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the CTLH complex . Gene . 396 . 2 . 236–47 . 2007 . 17467196 . 10.1016/j.gene.2007.02.032 .

Notes and References

1. Adams JC, Zhang L . cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH . Cytogenet Cell Genet . 87 . 1–2 . 19–21 . May 2000 . 10640805 . 10.1159/000015385 . 7919425 .
2. Web site: Entrez Gene: MKLN1 muskelin 1, intracellular mediator containing kelch motifs.
3. Umeda . M . Nishitani H . Nishimoto T . Jan 2003 . A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM . Gene . 303 . 47–54 . Netherlands. 0378-1119. 12559565 . 10.1016/S0378-1119(02)01153-8 .