Murphy Roths large explained

Murphy Roths large (MRL/MpJ) is a strain of laboratory mouse developed in 1999 at The Wistar Institute in Philadelphia, Pennsylvania.^[1] Originally bred for autoimmune disease research, it was discovered to have remarkable tissue regeneration abilities.^{[2] [3] [4]}

Research

The MRL/MpJ mouse strain was selectively bred by scientists to have an autoimmune genetic disorder (retained through inbreeding) to be used as a model for autoimmune disease research. After making puncture wounds in their ears, these mice were observed to completely regenerate from these wounds without development of scar tissue. In further research, this mouse strain has been observed to have the ability to also regenerate cardiac tissue, displays a resistance to muscle dystrophy, and is resistant to experiencing hyperglycemia from a diet high in fats.^{[5] [6] [7]}

External links

• The Wistar Institute: Ellen Heber-Katz, Ph.D. Research

Notes and References

1. Clark. Lise Desquenne. Clark. Robert K.. Heber-Katz. Ellen. July 1998. A New Murine Model for Mammalian Wound Repair and Regeneration. Clinical Immunology and Immunopathology. 88. 1. 35–45. 10.1006/clin.1998.4519. 9683548. 3734804 . 0090-1229.
2. Book: Heber-Katz . E. . Leferovich . J. M. . Bedelbaeva . K. . Gourevitch . D. . Spallanzani's Mouse: A Model of Restoration and Regeneration . Current Topics in Microbiology and Immunology . Regeneration: Stem Cells and Beyond . 280 . 165–89 . 2004 . 14594211 . 10.1007/978-3-642-18846-6_5. 978-3-642-62321-9 .
3. News: Mouse sheds light on regeneration . . 11 April 2006 . Rebecca . Morelle . Rebecca Morelle .
4. News: Self-healing Mice . ScienCentral News . https://web.archive.org/web/20081020095559/http://www.sciencentral.com/articles/view.php3?article_id=218392774&cat=1_2 . 20 October 2008 . 18 April 2006 . Lindsay . Carswell.
5. Heber-Katz. Ellen. Leferovich. John M.. Bedelbaeva. Khamilia. 2001-12-01. Spontaneous heart regeneration in adult MRL mice after cryoinjury. Gene Therapy and Regulation. 1. 4. 399–407. 10.1163/156855801760107055. 1568-5586.
6. Heydemann. Ahlke. Swaggart. Kayleigh. Kim. Gene H. Holley-Cuthrell. Jenan. Hadhazy. Michele. McNally. Elizabeth M. 2012. The superhealing MRL background improves muscular dystrophy. Skeletal Muscle. 2. 1. 26. 10.1186/2044-5040-2-26. 3534636. 23216833. 2044-5040. free.
7. Mull. Aaron J.. Berhanu. Tirsit K.. Roberts. Nathan W.. Heydemann. Ahlke. December 2014. The Murphy Roths Large (MRL) mouse strain is naturally resistant to high fat diet-induced hyperglycemia. Metabolism. 63. 12. 1577–1586. 10.1016/j.metabol.2014.09.007. 25308446. 4252560. 0026-0495.