Murid gammaherpesvirus 68 explained

Murid gammaherpesvirus 68 (MuHV-68) is an isolate of the virus species Murid gammaherpesvirus 4, a member of the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family of Herpesviridae. MuHV-68 serves as a model for study of human gammaherpesviruses which cause significant human disease including B-cell lymphoma and Kaposi's sarcoma. The WUMS strain of MuHV-68 was fully sequenced and annotated in 1997,[1] and the necessity of most of its genes in viral replication was characterized by random transposon mutagenesis.[2]

Surface proteins

Alpha-, beta-, and gammaherpesviruses display a heterodimer composed of glycoprotein H (gH) and glycoprotein L (gL) on their envelopes. This receptor is involved in the cell-to-cell transmission of the virus. Glycoprotein H has two conformations. Glycoprotein L is a chaperone protein which assures that gH takes on the correct conformation. Murid gammaherpesvirus 68 lack gL, gH misfolds. When alpha- or betaherpesviruses lack gL, they are noninfectious. Murid gammaherpesvirus 68 lacks gL, it remains infectious but is less able to bind to fibroblasts and epithelial cells.[3]

The open reading frame M7 of the MuHV-68 genome encodes for the surface receptor glycoprotein 150 (gp150). It is homologous to the Epstein-Barr virus membrane antigen gp350/220. MuHV-68 is more closely related to the Kaposi's Sarcoma-associated herpesvirus (KSHV) than it is to the Epstein-Barr virus. Glycoprotein K8.1 is the KSHV homolog of MuHV-68 gp150.[4] MuHV-68 is a very close relative of MuHV-72. The MuHV-68 M7 gene differs from the corresponding MuHV-72 gene by five point mutations which alter four codons.[5] Glycoprotein 150 allows MuHV-68 to bind to B-cells.[4]

Notes and References

  1. Journal of Virology . August 1997 . 5894–904 . 71 . 8 . Complete sequence and genomic analysis of murine gammaherpesvirus 68 . Herbet W. Virgin IV . Philip Latreille . Pamela Wamsley . Kymberlie Hallsworth . Karen E. Weck . Albert J. Dal Canto . Samuel H. Speck . 10.1128/JVI.71.8.5894-5904.1997 . amp . 9223479 . 191845.
  2. Proceedings of the National Academy of Sciences of the United States of America . March 2005 . 3805–10 . 102 . 10 . 10.1073/pnas.0404521102 . Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis . Moon Jung Song . Seungmin Hwang . Wendy H. Wong . Ting-Ting Wu . Sangmi Lee . Hsiang-I Liao . Ren Sun . amp . 15738413 . 553290. 2005PNAS..102.3805S . free .
  3. Journal of Virology . January 2007 . 280–291 . 81 . 1 . Glycoprotein L Disruption Reveals Two Functional Forms of the Murine Gammaherpesvirus 68 Glycoprotein H . Laurent Gillet . Janet S. May . Susanna Colaco . Philip G. Stevenson . amp . 10.1128/jvi.01616-06 . 17050601 . 1797276.
  4. Journal of Virology . October 2004 . 10449–10459 . 78 . 19 . In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis . James P. Stewart . Ondine J. Silvia . Isobel M. D. Atkin . David J. Hughes . Bahram Ebrahimi . Heiko Adler . amp . 10.1128/jvi.78.19.10449-10459.2004 . 15367611 . 516434.
  5. Virus Genes . Jan 2003 . 26. Murine gammaherpesvirus (MuHV) M7 gene encoding glycoprotein 150 (gp150): difference in the sequence between 72 and 68 strains . Macáková K, Matis J, Rezuchová I, Kúdela O, Raslová H, Kúdelová M . 12683351 . 1 . 89–95 . 10.1023/a:1022390407991. 34818785 .

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