Murid gammaherpesvirus 4 explained

Murid gammaherpesvirus 4 (MuHV-4) is a species of virus in the genus Rhadinovirus. It is a member of the subfamily Gammaherpesvirinae in the family Herpesviridae. This species infects mice via the nasal passages and causes an acute infectious mononucleosis-like syndrome with elevated levels of leukocytes, and shifts in the relative proportion of lymphocytes along with the appearance of atypical mononuclear cells.^[1] Murid gammaherpesvirus 4 currently serves as a model for study of human gammaherpesvirus pathogenesis.^[2]

Strains

Seven strains of Murid gammaherpesvirus 4 have been isolated, including the following six:

• MuHV-Šum
• MuHV-60
• MuHV-68
• MuHV-72
• MuHV-76
• MuHV-4556

Notes and References

1. Comparison of pathogenic properties of the murid gammaherpesvirus (MuHV 4) strains: a role for immunomodulatory proteins encoded by the left (5'-)end of the genome . Central European Journal of Biology . 3. 1 / March, 2008 . Jela Mistríková . Július Rajčáni . amp . 10.2478/s11535-008-0002-0. 2008 . free .
2. Murine gammaherpesvirus (MHV) MK3 gene sequence diversity among 72, 4556, and 68 strains . Virus Genes . 33. Valovicová M, Rezuchorá I, Macáková K, Petrová P, Matis J, Kúdelová M . 16791419 . 10.1007/s11262-005-0038-4 . 2006 . 51–8 . 1. 25195454 .