| Mulukuku | |
| Settlement Type: | Municipality |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | North Caribbean Coast Autonomous Region |
| Unit Pref: | Imperial |
| Area Total Km2: | 1330 |
| Population As Of: | 2022 estimate |
| Population Footnotes: | [1] |
| Population Note: | Estimate |
| Population Total: | 76306 |
| Population Density Km2: | auto |
| Population Urban: | 18503 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Timezone: | Central Time |
| Utc Offset: | -6 |
| Timezone Dst: | No DST |
| Utc Offset Dst: | -6 |
| Coordinates: | 13.15°N -83.97°W |
Mulukuku is a town and a municipality in the North Caribbean Coast Autonomous Region of Nicaragua.It was established as an asentamiento, or refugee community, during the early years of the war with the contra. People who lived in the remote rural areas and who were threatened by the contras, were brought to Mulukuku for safety. During the war a training school for the Nicaraguan army was located in the community. The community straddled the only road in the region that connected the Department of Matagalpa with Lisawe, Siuna, and eventually Puerto Cabezas. A large bridge crossing the Rio Tuma had been under construction and was nearly complete, when, in October 1988, Hurricane Joan struck Nicaragua. The bridge was destroyed and the community devastated. The national government committed to reconstruction and the community has flourished since that time. With the bridge complete, Mulukuku has become a regional commercial center. "Mulukukú" is a word in Miskito language that means Rivera de Sahinos.
On February 20, 2020, José Benito López Méndez, 51, leader of Ciudadanos por la Libertad ("Citizens for Liberty," an opposition political party) was kidnapped and shot six times in Mulukuku.[2]