| Official Name: | Mukhino |
| Native Name: | Мухино |
| Settlement Type: | Selo |
| Pushpin Map: | Russia Amur Oblast#Russia |
| Subdivision Type: | Country |
| Subdivision Name: | Russia |
| Subdivision Name1: | Amur Oblast |
| Subdivision Name3: | Shimanovsky District |
| Subdivision Type4: | Municipality |
| Utc Offset1: | +9:00 |
| Coordinates: | 52.2667°N 139°W[1] |
Mukhino (Russian: Мухино) is a rural locality (a selo) and the administrative center of Mukhinsky Selsoviet of Shimanovsky District, Amur Oblast, Russia. The population was 850 as of 2018.[2] There are 18 streets.
Mukhino is located 62 km northwest of Shimanovsk (the district's administrative centre) by road. Mukhinskaya is the nearest rural locality.[3]