Barbara Mukambu Mbandi (died 1666) was the queen regnant of the Kingdom of Ndongo and Matamba from 1663 to 1666. Also known as Kambu.
She was the sister of queen Ana I Nzinga, who united the kingdoms of Ndongo and Matamba. Her sister arranged for her to marry her general João Guterres Ngola Kanini, and appointed her as her designated heir and successor. Barbara was taken captive by the Portuguese, and kept hostage during the negotiations between them and her sister. In 1656, in connection to the release of Barbara from Portuguese custody in exchange for hundreds of slaves, Nzinga signed a peace treaty with the Portuguese and re-converted to Catholicism. After the death of Nzinga, Barbara succeeded her on the throne. She and her spouse had to fight Njinga Mona for the throne in a civil war that did not end until their son succeeded to the throne in 1680.