| Muisne River | |
| Pushpin Map: | Ecuador |
| Pushpin Map Caption: | Mouth location in Ecuador |
| Mouth Coordinates: | 0.6282°N -80.0418°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Ecuador |
The Muisne River is a river of Ecuador that enters the Pacific Ocean in the Esmeraldas Province.
The Muisne River is the main river in Cojimíes sub-region of the Manabí mangroves ecoregion.It discharges into the Pacific.The low-keyed Muisne resort is in the northern part of the Ensenada de Mompiche, on a sand bar among the mangroves of the Muisne River estuary.It may be reached by ferry across the Muisne River from the small town of El Relleno.