| Muhammad Isnaini | |
| Birth Date: | 10 September 1981 |
| Birth Place: | Pekanbaru, Indonesia |
| Position: | Forward |
| Years1: | 2000–2001 |
| Clubs1: | PS Karimun |
| Caps1: | 8 |
| Goals1: | 2 |
| Years2: | 2001–2003 |
| Clubs2: | PS Pelalawan |
| Caps2: | 17 |
| Goals2: | 6 |
| Years3: | 2003–2005 |
| Clubs3: | Persires Rengat |
| Caps3: | 26 |
| Goals3: | 11 |
| Years4: | 2005–2006 |
| Clubs4: | Riau Pos FC |
| Caps4: | 14 |
| Goals4: | 8 |
| Years5: | 2006–2015 |
| Clubs5: | PSPS Pekanbaru |
| Caps5: | 120 |
| Goals5: | 40 |
| Years6: | 2015 |
| Clubs6: | PSS Sleman |
| Caps6: | 4 |
| Goals6: | 0 |
| Pcupdate: | 18 April 2019 |
Muhammad Isnaini (born 10 September 1981 in Pekanbaru) is an Indonesian former footballer.[1] He is also a Police Brigadier in the Indonesian National Police.[2]