Muhammad Imran Qadir Explained

Muhammad Imran Qadir
Birth Date:3 September 1978
Birth Place:Shujabad, Multan, Pakistan
Field:Molecular Biology, Biochemistry
Work Institution:Bahauddin Zakariya University
Alma Mater:Bahauddin Zakariya University, Multan
Quaid-i-Azam University, Islamabad
Doctoral Advisor:Dr. Salman A. Malik
Known For:Cancer diagnostic test (Qadir test), Anti-HIV drug (Qadirvirtide), a theory of cancer etiology (Qadir theory), Drug for corona (QadirVID-19)
Awards:Best Young Research Scholar and PAS-Gold Medal

Muhammad Imran Qadir (Urdu: {{Nastaliq|محمد عمران قادر; born September 3, 1978), also known as M. I. Qadir, is a Pakistani pharmaceutical scientist, and biomedical scientist.[1] [2] [3] [4]

Life and education

Qadir received his early education from Shujabad, Multan. He received his B.Pharm degree from Bahauddin Zakariya University, Multan, Pakistan. Later he attended Quaid-i-Azam University, Islamabad and received his Ph.D degree in subject of Biochemistry and Molecular Biology.[5] [6]

He worked in the College of Pharmacy, Government College University (Faisalabad).[7]

He then became a researcher and professor (associate) at Bahauddin Zakariya University, Multan, Pakistan.[8] There, he is heading "Phage Therapy & Drug Design Laboratory" of Institute of Molecular Biology and Biotechnology.[9]

Research contributions

  1. Qadir test: Qadir invented a medical test, known as the Qadir test, for diagnosis of cancer.[10] The approach takes a few hours using standard laboratory equipment for the analysis of plasma lipids (triglycerides, cholesterol, LDL-cholesterol and HDL-cholesterol) and a change in the lipid profile is used as marker for diagnosis of cancer. A number of prospective studies were carried out by the researcher by taking fasting blood samples of study subjects from all the major four types of cancers: carcinomas, sarcomas, lymphomas, and leukemias.[11]
  2. Qadirvirtide and Qadir-C30: His work also includes invention of anti-HIV drugs, Qadirvirtide[12] [13] [14] [15] and Qadir-C30.[16] [17] [18] These are fusion inhibitors that may be used as prophylaxis or for the treatment of AIDS. These are synthetic peptides composed of 36 and 30 amino acids respectively. These block the entry of HIV genome into human CD4 cells by binding to HR1 region of spike protein of HIV, so that the virus can not come close to the human cell membrane and ultimately fusion of the viral envelope with human cell membrane is prevented.[19]
  3. Qadir theory of cancer etiology: He has posed that viruses are the cause of cancer, the idea was presented as a theory of cancer etiology.[20] [21] [22] He postulated that "Viruses are the causative agents of cancer: 100% of cancer patients contain virus/es in their body which are responsible for the cancer." He also argued that some studies have opposed the idea, but he rejected them because laboratory methods were not used to detect viruses in those studies. The theory was concluded with the point that, in near future, viruses will be isolated from all cancer patients as causative agent of a specific cancer.[23]
  4. Qadirphages: He discovered local bacteriophages to be used as anti-bacterial products which were named as Qadirphages.[24] [25] The evolution of antibiotic resistance in bacteria has increased research in the field of therapies to search alternative methods to control the infections. Qadir isolated local phages, characterized them and found their antibacterial activities. The phages showed maximum propagation at 37 °C indicating that these work best at human body temperature. SDS-PAGE analysis confirmed the presence of protein cover and showed the various bands ranging from 10 to 200 kDa. Nucleic acid analysis confirmed the presence of RNA with a size of approximately 20 kb. Transmission electron microscopy indicated that the isolated phages belonged to Siphoviridae, Leviviridae, and Podoviridae families.[26]
  5. Fungal Research: He also discovered new genes in local fungi which are involved in curing skin diseases caused by these local fungi.[27]
  6. QadirVID-19: He designed a fusion inhibitor for specific treatment of COVID-19, which was named as QadirVID-19.[28] This drug is a synthetic peptide composed of 30 amino acids.[29] It is part of Heptad Repeat 2 (HR2) region of spike protein of 2019-nCoV which was found highly conserved region as it had 100% similarity, with BLAST scoring of 99.5 and E-value of 5e−24.[30]
  7. Publications: He has published more than 600 research articles.[31] [32] [33] He has also written and edited more 15 books in the field of medical sciences. Among them, "Rare and Uncommon Diseases"[34] [35] and "Bacterial Diseases"[36] are famous.
  8. Mentorship: He is an HEC approved supervisor for PhD research in Pakistan.[37] He has contributed in health-related community awareness programs.[38] [39]

Awards and recognition

Qadir was named best young research scholar by Higher Education Commission of Pakistan,[40] [41] and Productive Scientist of Pakistan, by Pakistan Council for Science and Technology, Ministry of Science and Technology (Pakistan).[42] [43] He received the Research Productivity Award, by Pakistan Council for Science and Technology, Ministry of Science and Technology (Pakistan).[44] He has also received a gold medal in the field of biotechnology from Pakistan Academy of Sciences (PAS).[45] [46] [47] [48] [49]

Fellowships and membership

Qadir is a Fellow of The Linnean Society of London, UK.[50] He is a member of the American Society for Microbiology[51] the International Dermoscopy Society (IDSS), Italy,[52] and the French Society for Cell Biology.[53] He is also member of other healthcare-related global societies.[54]

Notes and References

  1. News: Dr. Imran Declared Top Scientist In Pharma Science By PCST. 2019-07-09.
  2. Web site: Dr. Imran Declared Top Scientist In Pharma Science By PCST. UrduPoint. 2019-07-09.
  3. Web site: Top in Pharma Science (in Urdu). e.dunya.com.pk. 2019-07-09.
  4. Web site: Khabrain Epaper. generator. metatags. epaper.dailykhabrain.com.pk. 2019-07-09.
  5. Web site: Jang Multan 20.8.16. ResearchGate. 2019-07-09.
  6. Web site: Scientist invents new test to diagnose cancer. 2017-11-03. The Nation. 2019-07-09.
  7. Web site: Dr. M. Imran Qadir. PlacesMap. 2019-07-15.
  8. Web site: Personal Profile. 2019-07-09.
  9. Web site: Phage Therapy & Drug Design Laboratory. 2020-02-27.
  10. Web site: Muhammad Imran Qadir. KenzPub.
  11. Qadir. Muhammad Imran. 2016. Qadir test. Pakistan Journal of Pharmaceutical Sciences. 29. 247–248.
  12. Web site: HIV Fusion Inhibitors (definition). www.reference.md.
  13. Web site: Qadirvirtide - CTD. ctdbase.org.
  14. Qadir. Muhammad Imran. 2011. Qadirvirtide. Pakistan Journal of Pharmaceutical Sciences. 24. 4. 593–595. 21959827.
  15. Web site: PakMediNet. www.pakmedinet.com. 2019-07-09.
  16. Genetic Variation in the HR Region of the env Gene of HIV: A Perspective for Resistance to HIV Fusion Inhibitors. AIDS Research and Human Retroviruses. 2011. 10.1089/aid.2010.0098. 2019-12-09. Qadir. M.I.. Malik. S.A.. 27. 1. 57–63. 20874419. 44371106 .
  17. Web site: Qadirvirtide & Qadir-C30. BZUPAGES. 2019-12-09.
  18. Web site: Muhammad Imran Qadir. KenzPub. 2019-12-13.
  19. Web site: Qadirvirtide. Asian Digital Library.
  20. Web site: Multan professor presents theory on cancer cause. Samaa TV. 14 February 2017 .
  21. News: BZU Teacher Presents Theory On Cancer Cause. 2019-07-09.
  22. Web site: Roznama Dunya. e.dunya.com.pk. 2019-07-09.
  23. Qadir. Muhammad Imran. 2018. Qadir Theory of Cancer Etiology. Critical Reviews in Eukaryotic Gene Expression. 28. 1. 13–15. 10.1615/CritRevEukaryotGeneExpr.2018019561. 1045-4403. 29773012.
  24. Web site: Khabrain Epaper. generator. metatags. epaper.dailykhabrain.com.pk. 2019-07-09.
  25. Sajjad. Sahir. Qadir. Muhammad Imran. 2017. Phage Therapy against Streptococcus pneumoniae: Modern Tool to Control Pneumonia. Critical Reviews in Eukaryotic Gene Expression. 27. 4. 289–295. 10.1615/CritRevEukaryotGeneExpr.2017019527. 29283323. 1045-4403.
  26. Chauhdary. Zunera. Qadir. Muhammad Imran. 2018. Antibacterial Activity of Novel Strains of Bacteriophages: An Experimental Approach. Critical Reviews in Eukaryotic Gene Expression. 28. 1. 1–12. 10.1615/CritRevEukaryotGeneExpr.2017019608. 29773011. 1045-4403.
  27. Web site: Pakistani scientists discover new genes in fungus for skin disease cure. 2016-07-20.
  28. News: Formula for Medicine of Corona. Daily Express. 2020-09-15.
  29. Qadir. Muhammad Imran. QadirVID-19: A fusion inhibitor against Novel Coronavirus-2019 for specific management of COVID-19. Pak J Pharm Sci. 2020. 33. 5. 2187–2191. 10.36721/PJPS.2020.33.5.REG.2187-2191.1. 33824128.
  30. Web site: EBSCO's databases. QadirVID-19.
  31. Web site: Muhammad Imran Qadir - Google Scholar Citations. scholar.google.com.pk.
  32. Web site: Profile: M. Imran Qadir . ResearchGate.
  33. Web site: ORCID.
  34. Book: Rare and Uncommon Diseases . 9781527519503 . Qadir . Muhammad Imran . 16 October 2018 . Cambridge Scholars .
  35. Web site: National Library of Medicine .
  36. Book: Bacterial Diseases . 9789811473753 . Qadir . Muhammad Imran . 9 September 2020 . Bentham Science Pub .
  37. Web site: Search Engine for HEC Approved Supervisors (Eportal). www.hec.gov.pk. 2019-07-09.
  38. Web site: Cardiac problems: 'Stress, greasy food, lack of exercise unhealthy'. Tribune.com.pk. 2012-10-01. The Express Tribune. 2019-07-09.
  39. Web site: Kidney, bladder diseases: public awareness campaign launched. 2013-10-15. Business Recorder. 2019-07-09.
  40. Web site: HEC announces best young Pakistani research scholar. 27 June 2016. Times of Islamabad.
  41. Web site: Education single means to ensure socio-economic development: Rana Tanveer. www.thenews.com.pk. 2016-06-26.
  42. Web site: Productive Scientist 2010. gcuf.edu.pk. 2019-07-09.
  43. Book: Directory of Productive Scientists of Pakistan. Pakistan Council for Science & Technology. 2017. 283.
  44. Book: Research Productivity Award. Pakistan Council for Science & Technology. 2017. 24.
  45. News: Dr. Imran Qadir Received Gold Medal in Biotechnology. 2019-12-10.
  46. News: Jahan-e-Ilmo-adab. 2019-12-10.
  47. News: Roznama Express. 2019-12-11.
  48. News: Gold Medal. Naw-e-Waqat. 2019-12-13. Page 3, Column 3.
  49. News: January 2020. PAS Gold Medals, Prizes and Certificates-2019. PAS Newsletter. Page.3. 2020-08-23.
  50. April 2019. Fellows Elected, Oct 2018-Jan 2019. The Linnean. 35. 41.
  51. Web site: Member Profile View. myasm.asm.org. 2019-07-09.
  52. Web site: List of IDS members – International Dermoscopy Society. 2019-07-09.
  53. Web site: Muhammad Imran Qadir, auteur sur SBCF. SBCF. 2019-07-09.
  54. Web site: Members Of Pakistan. Trialect. 2019-12-13.

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