Mucrolysin Explained

Mucrolysin
Ec Number:	3.4.24.54
Cas Number:	85898-38-0

Uniprot:	O57413
Zinc metalloproteinase/disintegrin
Organism:	Protobothrops mucrosquamatus

Mucrolysin (Trimeresurus metalloendopeptidase A, mucrotoxin A) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Cleavage of Ser⁹-His, His¹⁰-Leu, Ala¹⁴-Leu, Leu¹⁵-Tyr and Tyr¹⁶-Leu bonds in insulin B chain

This endopeptidase from the venom of Taiwan habu snake (Protobothrops mucrosquamatus).

Notes and References

1. Purification and properties of a lethal, hemorrhagic protein, "mucrotoxin A", from the venom of the Chinese habu snake (Trimeresurus mucrosquamatus) . Sugihara H, Moriura M, Nikai T . Toxicon . 1983 . 21 . 247–255 . 6857709 . 10.1016/0041-0101(83)90009-0.
2. Kishida M, Nikai T, Mori N, Kohmura S, Sugihara H . Characterization of mucrotoxin A from the venom of Trimeresurus mucrosquamatus (the Chinese habu snake) . Toxicon . 23 . 4 . 637–45 . 1985 . 3904081 . 10.1016/0041-0101(85)90368-x .