Mucorpepsin Explained

Mucorpepsin
Ec Number:	3.4.23.23
Cas Number:	148465-73-0

Mucorpepsin (Mucor rennin, Mucor aspartic proteinase, Mucor acid proteinase, Mucor acid protease, Mucor miehei aspartic proteinase, Mucor miehei aspartic protease, Mucor pusillus emporase, Fromase 100, Mucor pusillus rennin, Fromase 46TL, Mucor miehei rennin) is an enzyme .^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, favouring hydrophobic residues at P1 and P1'. Clots milk. Does not accept Lys at P1, and hence does not activate trypsinogen

This enzyme is isolated from the zygomycete fungi Mucor pusillus and M. miehei.

Notes and References

1. Book: Milk-clotting enzyme from Mucor pusillus var. lindt . Arima K, Yu J, Iwasaki S . Milk-clotting enzyme from Mucor pusillus var. Lindt . Methods Enzymol. . 1970 . 19 . 446–459 . 10.1016/0076-6879(70)19033-1. 978-0-12-181881-4 .
2. Book: The acid protease of Mucor miehei . Ottesen M, Rickert W . Methods Enzymol. . 1970 . 19 . 459–460 . 10.1016/0076-6879(70)19034-3 .
3. Sternberg M . Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease . Biochimica et Biophysica Acta (BBA) - Protein Structure . 285 . 2 . 383–92 . December 1972 . 4573298 . 10.1016/0005-2795(72)90324-8 .
4. On the specificity of a rennin-like enzyme from Mucor pusillus . Oka T, Ishino K, Tsuzuki H, Morihara K, Arima K . Agric. Biol. Chem. . 1973 . 37 . 5 . 1177–1184 . 10.1271/bbb1961.37.1177. free .
5. Baudys M, Foundling S, Pavlík M, Blundell T, Kostka V . Protein chemical characterization of Mucor pusillus aspartic proteinase. Amino acid sequence homology with the other aspartic proteinases, disulfide bond arrangement and site of carbohydrate attachment . FEBS Letters . 235 . 1–2 . 271–4 . August 1988 . 3042459 . 10.1016/0014-5793(88)81277-8 . free . 1988FEBSL.235..271B .