Mucin 5B Explained

Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene[1] [2] [3] [4] and by the Muc5b gene in the mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases, such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease, the gene has been found to be upregulated, and this may be related to the pathogenesis of these conditions.[5]

Synthesis

All mucins are synthesized in secretory cells known as goblet cells or mucous cells, depending on the tissue location. Their creation, while still not completely understood, begins in the endoplasmic reticulum. From there, the Golgi apparatus builds the O-linked glycans found in mucins. Finally, they are packaged into secretory granules.[6]

Notes and References

  1. Desseyn JL, Buisine MP, Porchet N, Aubert JP, Laine A . Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon . The Journal of Biological Chemistry . 273 . 46 . 30157–64 . November 1998 . 9804771 . 10.1074/jbc.273.46.30157 . free .
  2. Desseyn JL, Guyonnet-Dupérat V, Porchet N, Aubert JP, Laine A . Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family . The Journal of Biological Chemistry . 272 . 4 . 3168–78 . November 1997 . 9013550 . 10.1074/jbc.272.6.3168 . free .
  3. Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A . Genomic organization of the 3' region of the human mucin gene MUC5B . The Journal of Biological Chemistry . 272 . 27 . 16873–83 . 1997 . 9201995 . 10.1074/jbc.272.27.16873 . free .
  4. Web site: Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming.
  5. Web site: MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human)] - Gene - NCBI]. 2021-06-10. www.ncbi.nlm.nih.gov.
  6. Book: McGuckin MA, Thornton DJ, Whitsett JA . Mucins and mucus. . Mucosal Immunology . January 2015 . 231–250 . Academic Press . 10.1016/B978-0-12-415847-4.00014-8 . 9780124158474 .

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