Mucin 17 Explained

Mucin-17 is a protein that in humans is encoded by the MUC17 gene.^{[1] [2]}

Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM]

Further reading

• Kitamoto S . DNA methylation and histone H3-K9 modifications contribute to MUC17 expression . Glycobiology . 21 . 2 . 247–56 . 2011 . 20926598 . vanc. Yamada N . Yokoyama S . 3 . 10.1093/glycob/cwq155 . Houjou . I . Higashi . M . Goto . M . Batra . SK . Yonezawa . S . 3010767 .
• Malmberg EK . The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine . Biochem. J. . 410 . 2 . 283–9 . 2008 . 17990980 . 10.1042/BJ20071068 . vanc. Pelaseyed T . Petersson AC . 3 . Seidler . Ursula E. . De Jonge . Hugo . Riordan . John R. . Hansson . Gunnar C. . 207870 .
• Moniaux N . Characterization of human mucin MUC17. Complete coding sequence and organization . J. Biol. Chem. . 281 . 33 . 23676–23685 . 2006 . 16737958 . 10.1074/jbc.M600302200 . vanc. Junker WM . Singh AP . 3 . Jones . AM . Batra . SK . free .
• Oh JH . Transcriptome analysis of human gastric cancer . Mamm. Genome . 16 . 12 . 942–954 . 2006 . 16341674 . 10.1007/s00335-005-0075-2 . vanc. Yang JO . Hahn Y . 3 . Kim . Mi-Rang . Byun . Sang-Soon . Jeon . Yeo-Jin . Kim . Jeong-Min . Song . Kyu-Sang . Noh . Seung-Moo . 69278 .
• Ho JJ . N-glycosylation is required for the surface localization of MUC17 mucin . Int. J. Oncol. . 23 . 3 . 585–92 . 2004 . 12888891 . 10.3892/ijo.23.3.585. vanc. Jaituni RS . Crawley SC . 3 . Yang . SC . Gum . JR . Kim . YS .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Wang R, Khatri IA, Forstner JF . C-terminal domain of rodent intestinal mucin Muc3 is proteolytically cleaved in the endoplasmic reticulum to generate extracellular and membrane components . Biochem. J. . 366 . Pt 2 . 623–31 . 2002 . 12027806 . 10.1042/BJ20020289 . 1222797 .
• Van Klinken BJ . Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region . Biochem. Biophys. Res. Commun. . 238 . 1 . 143–148 . 1997 . 9299468 . 10.1006/bbrc.1997.7258 . vanc. Van Dijken TC . Oussoren E . 3 . Büller . HA . Dekker . J . Einerhand . AW .

Notes and References

1. Gum JR Jr . Crawley SC . Hicks JW . Szymkowski DE . Kim YS . MUC17, a novel membrane-tethered mucin . Biochem Biophys Res Commun . 291 . 3 . 466–475 . Feb 2002 . 11855812 . 10.1006/bbrc.2002.6475 .
2. Web site: Entrez Gene: MUC17 mucin 17, cell surface associated.