| Native Name: | Région du Moyen-Comoé |
| Conventional Long Name: | Moyen-Comoé Region |
| Common Name: | Moyen-Comoé |
| Subdivision: | Region |
| Nation: | Ivory Coast |
| Status Text: | Defunct region of Ivory Coast |
| Capital: | Abengourou |
| Today: | Indénié-Djuablin Region |
| Year Start: | 1997 |
| Year End: | 2011 |
| Event Start: | Established as a first-level subdivision |
| Image Map Caption: | Location of Moyen-Comoé Region in Ivory Coast |
| Stat Area1: | 6921 |
Moyen-Comoé Region is a defunct region of Ivory Coast. From 1997 to 2011, it was a first-level subdivision region. The region's capital was Abengourou and its area was 6,921 km2.[1] Since 2011, the area formerly encompassed by the region is the second-level Indénié-Djuablin Region in Comoé District.[2]
At the time of its dissolution, Moyen-Comoé Region was divided into three departments: Abengourou, Agnibilékrou, and Bettié.
Moyen-Comoé Region was abolished as part of the 2011 administrative reorganisation of the subdivisions of Ivory Coast. The area formerly encompassed by the region is now Indénié-Djuablin Region. Indénié-Djuablin is one of two regions in the first-level Comoé District.