Motile sperm domain containing 3 explained
Motile sperm domain containing 3 is a protein that in humans is encoded by the MOSPD3 gene.[1]
Function
This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described.
Further reading
- Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A . Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes . Genome Research . 8 . 10 . 1060–73 . October 1998 . 9799793 . 310788 . 10.1101/gr.8.10.1060 .
- Pall GS, Wallis J, Axton R, Brownstein DG, Gautier P, Buerger K, Mulford C, Mullins JJ, Forrester LM . A novel transmembrane MSP-containing protein that plays a role in right ventricle development . Genomics . 84 . 6 . 1051–9 . December 2004 . 15533722 . 10.1016/j.ygeno.2004.08.017 .
- Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AW, Akkermans JJ, Wijdeven RH, Janssen GM, van Veelen PA, Neefjes J . Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs . Cell Reports . 33 . 10 . December 2020 . 108475 . 33296653 . 10.1016/j.celrep.2020.108475 . 228090430 . free . 1887/3184381 . free .
Notes and References
- Web site: Entrez Gene: Motile sperm domain containing 3 .
