Mosapramine Explained

Mosapramine (Cremin) is an atypical antipsychotic used in Japan for the treatment of schizophrenia.^{[1] [2]} It is a potent dopamine antagonist with high affinity to the D₂, D₃, and D₄ receptors,^[3] and with moderate affinity for the 5-HT₂ receptors.^[4]

See also

• Carpipramine
• Clocapramine
• Fluspirilene (typical antipsychotic)
• Imidazopyridine

Notes and References

1. Takahashi N, Terao T, Oga T, Okada M . Comparison of risperidone and mosapramine addition to neuroleptic treatment in chronic schizophrenia . Neuropsychobiology . 39 . 2 . 81–5 . 10072664 . 10.1159/000026565 . 1999 . 6554048 .
2. Book: Miyamoto S . Mosapramine . 2010 . https://doi.org/10.1007/978-3-540-68706-1_1839 . Encyclopedia of Psychopharmacology . 76 . Stolerman IP . Berlin, Heidelberg . Springer . en . 10.1007/978-3-540-68706-1_1839 . 978-3-540-68706-1 . 21 March 2022.
3. Futamura T, Ohashi Y, Yano K, Takahashi Y, Haga K, Fukuda T . [The affinities of mosapramine for the dopamine receptor subtypes in human cell lines expressing D2, D3 and D4 receptors] . Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica . 107 . 5 . 247–53 . May 1996 . 8690306 . 10.1254/fpj.107.247 . free .
4. Sumiyoshi T, Suzuki K, Sakamoto H, Yamaguchi N, Mori H, Shiba K, Yokogawa K . Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy . Neuropsychopharmacology . 12 . 1 . 57–64 . February 1995 . 7766287 . 10.1016/0893-133X(94)00064-7 .