Moronic acid explained
Moronic acid (3-oxoolean-18-en-28-oic acid) is a natural triterpene.[1] [2] Moronic acid can be extracted from Rhus javanica, a sumac plant traditionally believed to hold medicinal applications.[2] The molecule has also been extracted from mistletoe (Phoradendron reichenbachianum).[3]
Bevirimat, a derivative of the related triterpenoid betulinic acid, is under development as an anti-HIV drug; however, moronic acid has shown better antiviral profiles in vitro than bevirimat.[4] A particular moronic acid derivative showed potent anti-HIV activity with EC50 values of 0.0085 μM against NL4-3, 0.021 μM against PI-R (a multiple protease inhibitor resistant strain), and 0.13 μM against FHR-2 (an HIV strain resistant to (bevirimat). This derivative has become a new lead for clinical trials and is also active against herpes simplex virus 1.[4]
External links
Notes and References
- Web site: Comparative Toxicogenomics Database: moronic acid.
- 10086989 . 1999 . Kurokawa . Masahiko . Basnet . Purusotam . Ohsugi . Mizue . Hozumi . Toyoharu . Kadota . Shigetoshi . Namba . Tsuneo . Kawana . Takashi . Shiraki . Kimiyasu . Anti-Herpes Simplex Virus Activity of Moronic Acid Purified from Rhus javanica In Vitro and In Vivo . 289 . 1 . 72–8 . The Journal of Pharmacology and Experimental Therapeutics .
- 10.1055/s-2001-15823 . Cytotoxic Activity of Moronic Acid and Identification of the New Triterpene 3,4-seco-Olean-18-ene-3,28-dioic Acid from Phoradendron reichenbachianum . 2001 . Rios . María Yolanda . Salinas . David . Villarreal . María Luisa . Planta Medica . 67 . 5 . 443–6 . 11488459.
- 5462–9 . 10.1021/jm0601912 . 2512972 . Anti-AIDS Agents 69. Moronic Acid and Other Triterpene Derivatives as Novel Potent Anti-HIV Agents . 2006 . Yu . Donglei . Sakurai . Yojiro . Chen . Chin-Ho . Chang . Fang-Rong . Huang . Li . Kashiwada . Yoshiki . Lee . Kuo-Hsiung . Journal of Medicinal Chemistry . 49 . 18 . 16942019.
