Morogoro virus explained

Morogoro virus is an East African arenavirus infecting the multimammate mouse (Mastomys natalensis).[1] The virus is genetically closely related to Lassa virus, known to cause Lassa fever in humans. Morogoro virus, however, does not seem to infect humans.[1] Transmission of Morogoro virus between mice is assumed to occur via direct and indirect contact.[2] Infected animals pass a latent period of 7 days and subsequently shed the virus for about 30 days, after which they recover and develop lifelong antibodies.[3] Transmission may also be possible from infected mothers to offspring and through sexual contact, as this has been suggested for other arenaviruses.[4] [5]

Notes and References

  1. Günther S, Hoofd G, Charrel R, Röser C, Becker-Ziaja B, Lloyd G, Sabuni C, Verhagen R, van der Groen G, Kennis J, Katakweba A, Machang'u R, Makundi R, Leirs H . December 2009 . Mopeia virus-related arenavirus in natal multimammate mice, Morogoro, Tanzania . Emerg Infect Dis . 15 . 12 . 2008–2012 . 10.3201/eid1512.090864 . 3044542 . 19961688.
  2. Borremans B, Leirs H, Gryseels S, Günther S, Makundi R, de Bellocq JG . August 2011 . Presence of Mopeia virus, an African arenavirus, related to biotope and individual rodent host characteristics: implications for virus transmission . Vector Borne Zootic Dis . 11 . 8 . 1125–1131 . 10.1089/vbz.2010.0010 . 21142956.
  3. Borremans B, Vossen R, Becker-Ziaja B, Gryseels S, Hughes N, Van Gestel M, Van Houtte N, Günther S, Leirs H . 29 May 2015 . Shedding dynamics of Morogoro virus, an African arenavirus closely related to Lassa virus, in its natural reservoir host Mastomys natalensis . Sci Rep . 5 . 10445 . 10.1038/srep10445 . 4448520 . 26022445. 2015NatSR...510445B .
  4. Fichet-Calvet E, Becker-Ziaja B, Koivogui L, Günther S . September 2014 . Lassa serology in natural populations of rodents and horizontal transmission . Vector Borne Zoonotic Dis . 14 . 9 . 665–674 . 10.1089/vbz.2013.1484 . 4170823 . 25229705.
  5. Webb PA, Justines G, Johnson KM . 1975 . Infection of wild and laboratory animals with Machupo and Latino viruses . Bull World Health Organ . 52 . 4–6 . 493–499 . 2366657 . 182399.

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