| Office: | Mayor of Jerusalem |
| Term Start: | 1 November 1959 |
| Term End: | 29 November 1965 |
| Predecessor: | Gershon Agron |
| Successor: | Teddy Kollek |
| Birth Place: | Lithuania, Russian Empire |
| Death Date: | (age 88 or 89) |
| Death Place: | Jerusalem, Israel |
| Party: | Mapai |
Mordechai Ish-Shalom (he|מרדכי איש-שלום), (1902–1991), was an Israeli politician and labor leader. He was the Mayor of West Jerusalem from 1959 to 1965.
Mordechai Ish-Shalom was born in Lithuania during the reign of the Russian Empire. He immigrated to Mandate Palestine in 1923. His labor career began in the Stonecutters' Union in 1935; he then rose through the ranks of the Histadrut, the Israeli trade union congress.
In 1964, Ish-Shalom established an interdisciplinary professional team to plan the modernization of Jerusalem.[1]
In the 1970s, he was instrumental in the development of Kiryat Wolfson, a five-tower high-rise project overlooking Sacher Park.[2]
Ish-Shalom died on 21 February 1991.[3]