Moperone Explained

Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class[1] which is marketed in Japan for the treatment of schizophrenia. It is an antagonist for the D2 (Ki 0.7–1.9 nM), D3 (Ki 0.1–1 nM), and 5-HT2A (Ki 52 nM) receptors. It also has a high binding affinity for the sigma receptors.[2] [3]

Notes and References

  1. Gross H, Kaltenbäck E . The clinical position of moperone among the butyrophenones . Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry . 23 . 1 . 4–9 . 1969 . 5354545 . 10.3109/08039486909132154 .
  2. Book: Miyamoto S . Moperone . 2010 . https://doi.org/10.1007/978-3-540-68706-1_1838 . Encyclopedia of Psychopharmacology . 798 . Stolerman IP . Berlin, Heidelberg . Springer . 10.1007/978-3-540-68706-1_1838 . 978-3-540-68706-1 . 21 March 2022.
  3. Web site: PDSP Ki Database . Psychoactive Drug Screening Program (PDSP). Bryan Roth . Roth BL, Driscol J . University of North Carolina at Chapel Hill and the United States National Institute of Mental Health . 21 March 2022 .

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