| Monsampolo del Tronto | |
| Official Name: | Comune di Monsampolo del Tronto |
| Coordinates: | 42.8833°N 60°W |
| Region: | Marche |
| Province: | Ascoli Piceno (AP) |
| Mayor: | Pierluigi Caioni |
| Area Total Km2: | 15.43 |
| Population Footnotes: | [1] |
| Population Total: | 4530 |
| Population As Of: | 31 October 2017 |
| Population Demonym: | Monsampolesi |
| Elevation M: | 184 |
| Postal Code: | 63030 |
| Area Code: | 0735 |
Monsampolo del Tronto is a comune (municipality) in the Province of Ascoli Piceno in the Italian region Marche, located about 80km (50miles) south of Ancona and about 18km (11miles) southwest of Ascoli Piceno.
Monsampolo del Tronto borders the following municipalities: Acquaviva Picena, Castorano, Controguerra, Monteprandone, Offida, Spinetoli.