Monocyte distribution width explained

Monocyte distribution width
Purpose:	measure of the range of variation of monocyte volume
Synonyms:	MDW

Monocyte distribution width (MDW) is a cytometry-based parameter that measures the range of variation of monocytes. If the parameter is available, it is reported as part of the standard complete blood count (CBC) with differential.^[1]

The parameter was FDA cleared as an early sepsis indicator for ER patients in 2019 for Beckman Coulter.^{[2] [3]}

MDW serves as an indicator for early screening of sepsis in conjunction with CRP and PCT and for differentiating false positive blood cultures.^{[4] [5]}

Notes and References

1. Web site: Bentahar . Ahmed . What is Monocyte Distribution Width . . en . Sep 1, 2022.
2. News: Beckman Coulter's Early Sepsis Indicator Receives 510(k) Clearance from the U.S. Food and Drug Administration . www.beckmancoulter.com . April 18, 2019 . en.
3. Web site: FDA Product Classification . FDA.
4. Jo . Sung Jin . Kim . Sei Won . Choi . Jung-Hyun . Choi . Seoung Pill . Lee . Jehoon . Lim . Jihyang . Monocyte distribution width (MDW) as a useful indicator for early screening of sepsis and discriminating false positive blood cultures . PLOS ONE . 20 December 2022 . 17 . 12 . e0279374 . 10.1371/journal.pone.0279374 . free . 36538555 . 9767324. 2022PLoSO..1779374J .
5. Paxton . Anne . For sepsis Dx, MDW biomarker brought into the mix - CAP TODAY . CAP Today . 18 July 2023 . 16 April 2024.