Monocarboxylate transporter 5 explained

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.^{[1] [2]}

See also

• Solute carrier family

Further reading

• Halestrap AP, Price NT . The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation . The Biochemical Journal . 343 . 2 . 281–99 . October 1999 . 10510291 . 1220552 . 10.1042/bj3430281 .
• Halestrap AP, Meredith D . The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond . Pflügers Archiv . 447 . 5 . 619–28 . February 2004 . 12739169 . 10.1007/s00424-003-1067-2 . 15498611 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Pilegaard H, Terzis G, Halestrap A, Juel C . Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle . The American Journal of Physiology . 276 . 5 Pt 1 . E843-8 . May 1999 . 10.1152/ajpendo.1999.276.5.E843 . 10329977 .
• Manning Fox JE, Meredith D, Halestrap AP . Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle . The Journal of Physiology . 529 . 2 . 285–93 . December 2000 . 11101640 . 2270204 . 10.1111/j.1469-7793.2000.00285.x .
• Philp NJ, Wang D, Yoon H, Hjelmeland LM . Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells . Investigative Ophthalmology & Visual Science . 44 . 4 . 1716–21 . April 2003 . 12657613 . 10.1167/iovs.02-0287 . free .
• Juel C, Holten MK, Dela F . Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans . The Journal of Physiology . 556 . Pt 1 . 297–304 . April 2004 . 14724187 . 1664883 . 10.1113/jphysiol.2003.058222 .
• Settle P, Mynett K, Speake P, Champion E, Doughty IM, Sibley CP, D'Souza SW, Glazier J . Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta . Placenta . 25 . 6 . 496–504 . July 2004 . 15135232 . 10.1016/j.placenta.2003.11.009 .
• Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP . Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70) . The Journal of Biological Chemistry . 280 . 29 . 27213–21 . July 2005 . 15917240 . 10.1074/jbc.M411950200 . free .
• Merezhinskaya N, Ogunwuyi SA, Fishbein WN . Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides . Molecular Genetics and Metabolism . 87 . 2 . 152–61 . February 2006 . 16403666 . 10.1016/j.ymgme.2005.09.029 .
• Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D . The effects of short-term sprint training on MCT expression in moderately endurance-trained runners . European Journal of Applied Physiology . 96 . 6 . 636–43 . April 2006 . 16408234 . 10.1007/s00421-005-0100-x . 10354316 .
• Ullah MS, Davies AJ, Halestrap AP . The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism . The Journal of Biological Chemistry . 281 . 14 . 9030–7 . April 2006 . 16452478 . 10.1074/jbc.M511397200 . free .
• Bishop D, Edge J, Thomas C, Mercier J . High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle . Journal of Applied Physiology . 102 . 2 . 616–21 . February 2007 . 17082373 . 10.1152/japplphysiol.00590.2006 . 336956 .

Notes and References

1. Price NT, Jackson VN, Halestrap AP . Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past . The Biochemical Journal . 329 . 2 . 321–8 . January 1998 . 9425115 . 1219047 . 10.1042/bj3290321.
2. Web site: Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5).