| Mokete Tsotetsi | |
| Fullname: | Mokete Reuben Tsotetsi |
| Birth Date: | 14 November 1982 |
| Birth Place: | Boipatong, South Africa |
| Position: | Central defender |
| Years1: | 2002–2003 |
| Clubs1: | Wits University |
| Caps1: | 0 |
| Goals1: | 0 |
| Years2: | 2003–2004 |
| Clubs2: | FC Sporting |
| Caps2: | 21 |
| Goals2: | 1 |
| Years3: | 2004–2007 |
| Clubs3: | Jomo Cosmos |
| Caps3: | 73 |
| Goals3: | 0 |
| Years4: | 2007–2009 |
| Clubs4: | Kaizer Chiefs |
| Caps4: | 36 |
| Goals4: | 2 |
| Years5: | 2009–2010 |
| Clubs5: | Bloemfontein Celtic |
| Caps5: | 18 |
| Goals5: | 0 |
| Years6: | 2010–2011 |
| Clubs6: | Vasco da Gama |
| Caps6: | 27 |
| Goals6: | 1 |
| Years7: | 2011–2012 |
| Clubs7: | Mpumalanga Black Aces |
| Caps7: | 0 |
| Goals7: | 0 |
| Years8: | 2013–2014 |
| Clubs8: | Roses United |
| Caps8: | 6 |
| Goals8: | 0 |
| Nationalyears1: | 2008 |
| Nationalteam1: | South Africa |
| Nationalcaps1: | 1 |
| Nationalgoals1: | 0 |
| Club-Update: | 18:09, 28 March 2015 (UTC) |
Mokete Reuben Tsotetsi (born 14 November 1982) is a South African international footballer who plays as a central defender.
Born in Boipatong, Tsotetsi has played for Wits University, FC Sporting, Jomo Cosmos, Kaizer Chiefs, Bloemfontein Celtic, Vasco da Gama, Mpumalanga Black Aces and Roses United.
He earned one cap for South Africa, which came in a FIFA World Cup qualifying match against Sierra Leone on 14 June 2008.