| Honorific-Prefix: | His Excellency |
| Office: | Minister of Industry |
| Term Start: | 23 September 2024 |
| President: | Bashar al-Assad |
| Primeminister: | Mohammad Ghazi al-Jalali |
| Predecessor: | Abdel Qader Jokhadar |
| Office1: | Minister of Economy and Foreign Trade |
| Term Start1: | 29 March 2017 |
| Term End1: | 23 September 2024 |
| President1: | Bashar al-Assad |
| Primeminister1: | Imad Khamis Hussein Arnous |
| Predecessor1: | Adeeb Mayala |
| Successor1: | Mohammad Rabie Qalaaji |
| Mohammad Samer al-Khalil | |
| Native Name Lang: | ar |
| Birth Place: | Damascus, Syria |
| Nationality: | Syrian |
| Residence: | Damascus |
| Alma Mater: | Damascus University |
| Profession: | Politician, Civil servant |
Mohammad Samer al-Khalil (ar|محمد سامر الخليل; born 1977) is a Syrian politician. He is currently serving as Minister of Industry.[1] [2]
He served in the Imad Khamis government, the First Hussein Arnous government and the Second Hussein Arnous government.[3]
He attended Expo 2020 and signed a trade deal with Emirati economy minister Abdulla bin Touq Al Marri.[4]