| Mogi-Guaçu Biological Reserve | |
| Alt Name: | Reserva Biológica de Mogi Guaçu |
| Iucn Category: | Ia |
| Map: | Brazil |
| Relief: | yes |
| Nearest City: | Mogi Mirim, São Paulo |
| Coordinates: | -22.285°N -47.177°W |
| Designation: | Biological reserve |
| Created: | 1942 |
Mogi-Guaçu Biological Reserve (pt|Reserva Biológica de Mogi Guaçu) is a biological reserve located in the state of São Paulo, Brazil.
The reserve was created by State Law nº. 12.500 of 1942 with an area of . The reserve is in the Martinho Prado Junior district of the municipality of Mogi Guaçu. It holds a research centre that investigates ecology, taxonomy, population genetics, physiology, biochemistry and other subjects.
The terrain is relatively flat, lying at above sea level. Average annual rainfall is . Average temperature is . Winters, from April to September, are dry.
The reserve contains one of the few remnants of cerrado in São Paulo State. Vegetation includes cerrado, riparian forests and fields.
It includes endangered species such as Aristolochia labiata, Eriotheca pubescens and the palms Acanthococos emensis and Euterpe edulis.Fauna include cougar (Puma concolor), giant anteater (Mymercophaga tridactyla), maned wolf (Chrysocyon brachyurus), black-collared hawk (Busarellus nigricollis) and red-winged tinamou (Rhynchotus rufescens). The black-fronted titi (Callicebus nigrifrons) occurs in the reserve.