| Official Name: | Mỏ Cày Nam district |
| Coordinates: | 10.1667°N 136°W |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Mekong Delta |
| Seat Type: | Capital |
| Seat: | Bến Tre |
| Leader Title: | People's Council Chair |
| Leader Name: | Nguyễn Thị Hồng |
| Leader Title1: | People's Committee Chair |
| Leader Name1: | NVõ Văn Út |
| Area Total Km2: | 219.88 |
| Population Total: | 143,577 |
| Population As Of: | April 1, 2019 |
| Population Density Km2: | 653 |
| Demographics Type1: | Demographics |
| Demographics1 Title1: | Ethnicities |
| Demographics1 Info1: | Vietnamese |
| Timezone: | ICT |
| Utc Offset: | +7 |
| Area Code Type: | Area codes |
| Area Code: | 75 (until 16 July 2017) 275 (from 17 June 2017) |
| Iso Code: | VN-50 |
Mỏ Cày Nam is a rural district (huyện) of Bến Tre province in the Mekong Delta of Vietnam. The district was established in March 2009.
Mỏ Cày Nam borders Giồng Trôm district to the east, Mỏ Cày Bắc and Giồng Trôm districts to the north and northeast, Thạnh Phú district to the south and southwest and Trà Vinh province to the south and west.
Mỏ Cày Nam has a population of 186,474 and covers an area of 219.9 km2.
This district is subdivided into 1 township (thị trấn) and 16 communes (xã):