| Official Name: | Mizque |
| Native Name: | Misk'i |
| Pushpin Map: | Bolivia |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Bolivia |
| Subdivision Type: | Country |
| Subdivision Name: | Bolivia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Cochabamba Department |
| Subdivision Type2: | Province |
| Subdivision Name2: | Mizque Province |
| Subdivision Type3: | Municipality |
| Subdivision Name3: | Mizque Municipality |
| Subdivision Type4: | Canton |
| Subdivision Name4: | Mizque Canton |
| Unit Pref: | Imperial |
| Population As Of: | 2001 |
| Population Total: | 26,659 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | BOT |
| Utc Offset: | -4 |
| Coordinates: | -17.9333°N -84°W |
| Elevation M: | 2018 |
Mizque, Misk'i (from Quechua: misk'i, meaning "sweet") is a town in the Cochabamba Department, Bolivia. It is the capital of the Mizque Province. Mizque is located in the valley of the Mizque River, one of the main tributaries of the Río Grande.
Historically, it was located in the region of Upper Peru, and was a corregimiente dependent on Santa Cruz de la Sierra until 1783, when it became an independent town of the Intendencia de Cochabamba, in the Viceroyalty of the Río de la Plata. During the Spanish American wars of independence, Mizque sent deputies to the Congress of Tucumán, which declared Argentina's independence in 1816, and to the congress that declared the independence of Bolivia in 1825.
Mizque is located on a well maintained highway which to the north-west leads through the Valle Alto to Cochabamba. In the other direction, as National Road 23, the route runs southwards to Aiquile and, beyond that, to Sucre.
The bus connection to Cochabamba operates on an almost daily basis.
Mizque is also positioned beside the Cochabamba-Aiquile railway line, but since the railway station is across the river it is hard for the inhabitants to access. There is a railcar service to Cochabamba that runs three times per week, but the journey time is approximately twice as long as that taken by the bus using the main road, and the station is not much used for passenger traffic.