Mitosene Explained

The mitosenes are a class of organic chemicals based on a quinone-containing three-ring structure related to the two-ring core of the indolequinones. They are derived from the mitomycins by reduction and are the active alkylating agents responsible for the antitumor activity of the mitomycins.^{[1] [2]}

Notes and References

1. Mitosene–DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon Reductive Activation . Maliepaard . Marc . de Mol . Nico J. . Tomasz . Maria . Gargiulo . Dario . Janssen . Lambert H. M. . van Duynhoven . John P. M. . van Velzen . Ewoud J. J. . Verboom . Willem . Reinhoudt . David N. . Biochemistry . 1997 . 36 . 30 . 9211–9220 . 10.1021/bi9700680 . 9230054.
2. A comparison of mechanisms proposed for the conversion of mitomycins into mitosenes . 1 Bhashyam S. . Iyengar . William A. . Remers . J. Med. Chem. . 1985 . 28 . 7 . 963–967 . 10.1021/jm00145a021 . 3925148 .