Mitoquinone mesylate explained

Mitoquinone mesylate (MitoQ) is a synthetic analogue of coenzyme Q10 which has antioxidant effects. It was first developed in New Zealand in the late 1990s.[1] It has significantly improved bioavailability and improved mitochondrial penetration compared to coenzyme Q10,[2] [3] and has shown potential in a number of medical indications,[4] [5] [6] [7] being widely sold as a dietary supplement.[8] [9]

A 2014 review found insufficient evidence for the use of mitoquinone mesylate in Parkinson's disease and other movement disorders.[10]

See also

Notes and References

  1. US . 20060229278 . Mitoquinone derivatives used as mitochondrially targeted antioxidants. . Taylor K, Smith R . Antipodean Pharmaceuticals Inc . 12 October 2006 . abandoned .
  2. Battogtokh G, Choi YS, Kang DS, Park SJ, Shim MS, Huh KM, Cho YY, Lee JY, Lee HS, Kang HC . 6 . Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives . Acta Pharmaceutica Sinica B . 8 . 6 . 862–880 . October 2018 . 30505656 . 10.1016/j.apsb.2018.05.006 . 6251809 .
  3. Gutierrez-Mariscal FM, Arenas-de Larriva AP, Limia-Perez L, Romero-Cabrera JL, Yubero-Serrano EM, López-Miranda J . Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases . International Journal of Molecular Sciences . 21 . 21 . October 2020 . 7870 . 33114148 . 10.3390/ijms21217870 . 7660335 . free .
  4. Silva FS, Simoes RF, Couto R, Oliveira PJ . Targeting Mitochondria in Cardiovascular Diseases . Current Pharmaceutical Design . 2016 . 22 . 37 . 5698–5717 . 27549376 . 10.2174/1381612822666160822150243 .
  5. Kezic A, Spasojevic I, Lezaic V, Bajcetic M . Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury . Oxidative Medicine and Cellular Longevity . 2016 . 2016 . 2950503 . 27313826 . 10.1155/2016/2950503 . 4894993 . free .
  6. Oliver DM, Reddy PH . Small molecules as therapeutic drugs for Alzheimer's disease . Molecular and Cellular Neurosciences . 96 . 47–62 . April 2019 . 30877034 . 10.1016/j.mcn.2019.03.001 . 6510253 .
  7. Ismail H, Shakkour Z, Tabet M, Abdelhady S, Kobaisi A, Abedi R, Nasrallah L, Pintus G, Al-Dhaheri Y, Mondello S, El-Khoury R, Eid AH, Kobeissy F, Salameh J . 6 . Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone . Antioxidants . 9 . 10 . October 2020 . 943 . 33019512 . 10.3390/antiox9100943 . 7601591 . free .
  8. Braakhuis AJ, Nagulan R, Somerville V . The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis . Oxidative Medicine and Cellular Longevity . 2018 . 2018 . 8575263 . 30116495 . 10.1155/2018/8575263 . 6079400 . free .
  9. Thoma A, Akter-Miah T, Reade RL, Lightfoot AP . Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function . Biogerontology . 21 . 4 . 475–484 . August 2020 . 32447556 . 10.1007/s10522-020-09883-x . 7347670 .
  10. Liu J, Wang LN . Mitochondrial enhancement for neurodegenerative movement disorders: a systematic review of trials involving creatine, coenzyme Q10, idebenone and mitoquinone . CNS Drugs . 28 . 1 . 63–8 . January 2014 . 24242074 . 10.1007/s40263-013-0124-4 . 207486107 .

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