Mitochondrial ribosomal protein L41 explained

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.^{[1] [2]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family.

Further reading

• Goldschmidt-Reisin S, Kitakawa M, Herfurth E, etal . Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. . J. Biol. Chem. . 273 . 52 . 34828–36 . 1999 . 9857009 . 10.1074/jbc.273.52.34828 . free .
• Koc EC, Burkhart W, Blackburn K, etal . The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. . J. Biol. Chem. . 276 . 47 . 43958–69 . 2001 . 11551941 . 10.1074/jbc.M106510200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Zhang Z, Gerstein M . Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. . Genomics . 81 . 5 . 468–80 . 2003 . 12706105 . 10.1016/S0888-7543(03)00004-1 .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chintharlapalli SR, Jasti M, Malladi S, etal . BMRP is a Bcl-2 binding protein that induces apoptosis. . J. Cell. Biochem. . 94 . 3 . 611–26 . 2005 . 15547950 . 10.1002/jcb.20292 . 23940695 .
• Yoo YA, Kim MJ, Park JK, etal . Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. . Mol. Cell. Biol. . 25 . 15 . 6603–16 . 2005 . 16024796 . 10.1128/MCB.25.15.6603-6616.2005 . 1190350 .
• Kim MJ, Yoo YA, Kim HJ, etal . Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). . Biochem. Biophys. Res. Commun. . 338 . 2 . 1179–84 . 2006 . 16256947 . 10.1016/j.bbrc.2005.10.064 .

Notes and References

1. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T . The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders . Genomics . 77 . 1–2 . 65–70 . Sep 2001 . 11543634 . 10.1006/geno.2001.6622 .
2. Web site: Entrez Gene: MRPL41 mitochondrial ribosomal protein L41.