Mitochondrial ribosomal protein L17 explained

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[1]

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Zhang Z, Gerstein M . Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome . Genomics . 81 . 5 . 468–80 . 2003 . 12706105 . 10.1016/S0888-7543(03)00004-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Tchernev VT, Mansfield TA, Giot L, etal . The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins . Mol. Med. . 8 . 1 . 56–64 . 2002 . 11984006 . 10.1007/bf03402003. 2039936 .
• Kenmochi N, Suzuki T, Uechi T, etal . The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders . Genomics . 77 . 1–2 . 65–70 . 2001 . 11543634 . 10.1006/geno.2001.6622 .
• Hu RM, Han ZG, Song HD, etal . Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning . Proc. Natl. Acad. Sci. U.S.A. . 97 . 17 . 9543–8 . 2000 . 10931946 . 10.1073/pnas.160270997 . 16901 . 2000PNAS...97.9543H . free .
• O'Brien TW, Fiesler SE, Denslow ND, etal . Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences . J. Biol. Chem. . 274 . 51 . 36043–51 . 2000 . 10593885 . 10.1074/jbc.274.51.36043 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .

Notes and References

1. Web site: Entrez Gene: MRPL17 mitochondrial ribosomal protein L17.