Misterioso means mysterious in the Italian language, and in the context of written music, is an instruction to the performer to play the music in a mysterious mood. It may also refer to:
"Misterioso", a composition by jazz pianist Thelonious Monk and the title for two of his albums
Misterioso, a 1991 TV film with Suzan Sylvester and Jack Shepherd, in which the eponymous Monk piece features prominently; aired as part of The Play on One series on BBC One.