| State: | MO |
| Type: | MO |
| Route: | 6 |
| Map Custom: | yes |
| Maint: | MoDOT |
| Established: | 1922 |
| Length Mi: | 211 |
| Length Round: | 0 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | in St. Joseph |
| Junction: |
|
| Terminus B: | south of Taylor |
| Previous Type: | MO |
| Previous Route: | 5 |
| Next Type: | MO |
| Next Route: | 7 |
Route 6 is a 211adj=midNaNadj=mid state highway in the northern part of the U.S. state of Missouri. It travels from I-29 Bus./US 169 in St. Joseph to US 24/US 61 about 6miles west of Quincy, Illinois. Route 6, if only a few miles longer in each direction, would be the only state highway to cross Missouri west to east. It is one of the original 1922 highways in Missouri.