| State: | MO |
| Type: | MO |
| Route: | 80 |
| Map Custom: | yes |
| Length Mi: | 27.302 |
| Direction B: | East |
| Direction A: | West |
| Junction: | near Matthews |
| Previous Type: | MO |
| Previous Route: | 79 |
| Next Type: | MO |
| Next Route: | 81 |
Route 80 is a state highway in southeastern Missouri. The route is located in northern New Madrid and central Mississippi Counties.
Route 80's western terminus is at U.S. Route 61/62 near Matthews, which is located midway between Sikeston and New Madrid, with a junction with I-55 located about a mile (1.6 km) to the east. East Prairie is the only other town on the highway. Its eastern terminus is a dead end at the Mississippi River in Belmont.
At Belmont, there used to be a ferry connecting Route 80 to Kentucky Route 80, which is a major east - west thoroughfare across southern Kentucky, continuing into Virginia, as Virginia State Route 80.[1] [2] [3] The toll ferry service was discontinued in 1984.[4] [5]