| State: | MO |
| Type: | MO |
| Route: | 2 |
| Map Custom: | yes |
| Maint: | MoDOT |
| Length Mi: | 69.478 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | at the Kansas state line |
| Junction: |
|
| Terminus B: | in Windsor |
| Previous Type: | MO |
| Previous Route: | 1 |
| Next Type: | MO |
| Next Route: | 3 |
Route 2 is a highway in western Missouri. Its western terminus is at the Kansas state line about 3miles southwest of West Line; it continues into Kansas as K-68. Its eastern terminus is at Route 52 in Windsor.
Route 2 begins at the Kansas state line in Cass County. The first town is passes through is West Line, followed by Freeman. In Harrisonville it has a brief concurrency with Interstate 49/U.S. Route 71 and Missouri Route 7. After splitting from I-49/US 71, it runs east into Johnson County, Missouri, crossing over near La Tour. It serves as the southern terminus of Route 131 before crossing Route 13 north of Postoak. It then runs through Leeton before entering Henry County. It then ends at Route 52.
Route 2 was initially Route 60, designated in 1922 between Leeton and Windsor. It was renumbered in 1926 due to US 60.