| State: | MO |
| Type: | MO 1948 |
| Route: | 4 |
| Established: | 1922 |
| Decommissioned: | 1960 |
| Length Mi: | 76 |
| Direction A: | West |
| Direction B: | East |
| Terminus A: | at the Nebraska state line |
| Terminus B: | in Stanberry |
| Previous Type: | MO |
| Previous Route: | 3 |
| Next Type: | MO |
| Next Route: | 5 |
Route 4 was a route that went from U.S. Route 136 (US 136) at the Nebraska state line to US 169 at the Iowa state line.