| State: | MO |
| Type: | Route |
| Route: | 38 |
| Map Custom: | yes |
| Length Mi: | 80.561 |
| Direction B: | East |
| Direction A: | West |
| Terminus B: | west of Houston |
| Junction: | in Marshfield |
| Terminus A: | south of Buffalo |
| Previous Type: | MO |
| Previous Route: | 37 |
| Next Type: | MO |
| Next Route: | 39 |
Route 38 is a highway in southern Missouri. Its eastern terminus is at Route 17 ten miles (16 km) west of Houston; its western terminus is at U.S. Route 65 about ten miles (16 km) south of Buffalo.