| State: | MO |
| Type: | MO |
| Route: | 168 |
| Map Custom: | yes |
| Map Notes: | MO 168 highlighted in red |
| Length Mi: | 42.578 |
| Direction A: | West |
| Terminus A: | in Shelbyville |
| Junction: | in Palmyra |
| Direction B: | East |
| Terminus B: | in Hannibal |
| Previous Type: | US |
| Previous Route: | 166 |
| Next Type: | US |
| Next Route: | 169 |
Route 168 is a highway in northeastern Missouri. Its eastern terminus is at U.S. Route 61 in Hannibal; its western terminus is at Route 15 in Shelbyville.