| State: | MO |
| Type: | Route |
| Route: | 161 |
| Map Custom: | yes |
| Map Notes: | MO 161 highlighted in red |
| Length Mi: | 42.299 |
| Direction A: | South |
| Terminus A: | at Danville |
| Direction B: | North |
| Terminus B: | at Bowling Green |
| Previous Type: | US |
| Previous Route: | 160 |
| Next Type: | MO |
| Next Route: | 162 |
Route 161 is a highway in northeastern Missouri. Its northern terminus is at Business U.S. Route 61 in Bowling Green; its southern terminus is at Interstate 70/U.S. Route 40 south of Montgomery City.
Missouri Route 161 was formerly known as Route 29.