| State: | MO |
| Type: | Route |
| Map Custom: | yes |
| Map Notes: | MO 153 highlighted in red |
| Route: | 153 |
| Length Mi: | 47.024 |
| Direction B: | North |
| Junction: | in Risco |
| Direction A: | South |
| Previous Type: | MO |
| Previous Route: | 152 |
| Next Type: | MO |
| Next Route: | 154 |
Route 153 is a highway in southeastern Missouri, United States. Its northern terminus is at U.S. Route 60 midway between Sikeston and Dexter. Its southern terminus is at Route 25 north of Kennett.