| State: | MO |
| Type: | MO |
| Route: | 111 |
| Map Custom: | yes |
| Map Notes: | MO 111 highlighted in red |
| Length Mi: | 46.108 |
| Direction A: | South |
| Terminus A: | in Oregon |
| Junction: | in Clay Township |
| Direction B: | North |
| Terminus B: | in Rock Port |
| Previous Type: | MO |
| Previous Route: | 110 |
| Previous Dab: | Jefferson County |
| Next Type: | MO |
| Next Route: | 112 |
Route 111 is a highway in northwestern Missouri. Its northern terminus is at U.S. Route 136 in Rock Port; its southern terminus is at U.S. Route 59 in Oregon. The entire length of Route 111 is part of the Lewis and Clark Trail.
Spur Route 111 is a 0.561adj=midNaNadj=mid spur route which connects to U.S. Route 59. It lies entirely within the city of Craig.